Clinical Studies (D)
Personalized preventive and therapeutic measures, i.e. the right treatment for the right patient group at the right time, are the objective of the clinical multicenter studies of the DZD. In addition, they elucidate healthcare economic aspects. A central unit for coordinating the clinical studies at the DZD office ensures a standardized and high-quality implementation.
The DZD is currently working on various studies on diabetes prevention (PLIS), on diabetes sequelae (DDS), on gestational diabetes (PREG) and on the prevention of type 1 diabetes (Pre-POINTearly).
Prediabetes Lifestyle Intervention Study (PLIS)
A conventional lifestyle intervention to prevent type 2 diabetes is not sufficient for all people with prediabetes. Only an individualized prevention strategy can be effective here. In the multicenter Prediabetes Lifestyle Intervention Study (PLIS), the DZD aims to develop such personalized preventive measures. After extensive phenotyping, the PLIS study participants undergo different lifestyle programs with nutritional counseling and supervised physical activity. The aim of the PLIS study is to find people who, despite increased efforts in everyday life, have an increased risk for type 2 diabetes and to offer them intensified lifestyle interventions supervised by a professional staff, so that these people, too, can benefit from a lifestyle modification. The study is being conducted at eight centers within the framework of the German Center for Diabetes Research (DZD). Here recruitment for the study has been concluded.
study record (in German)
Pre-POINTearly accepts children throughout Germany between the ages of 6 months and 2 years with a first-degree relative with type 1 diabetes into this study. Here researchers are investigating whether an oral intake of insulin can permanently prevent the development of type 1 diabetes. Pre-POINTearly is the follow-up study of the pre-POINT study in which a positive immune response in children between 2 and 7 years was triggered by using orally administered insulin powder. Insulin was administered prophylactically as a vaccine at a time when the children had not yet developed an autoimmune reaction – that is, had no autoantibodies.
DZD Prediabetes Cohort
Prediabetes is the precursor stage of diabetes in which the blood glucose levels are already abnormal. In order to develop personalized prevention strategies for type 2 diabetes, the DZD, based on previous studies, formed a unique prediabetes cohort that is unique in Germany with 8,106 participants who are continuously being investigated. In these patients, the blood glucose concentrations of the oral glucose tolerance test were abnormal at the time of enrollment in the study, but no diabetes was present. The current data analysis showed that a family history of diabetes can already increase the risk of prediabetes by 40 percent. The participants will be monitored in follow-up studies.
DZD Study Centers
Prof. Anette-Gabriele Ziegler
Helmholtz Zentrum München
Prof. Jochen Seißler, Dr. Andreas Lechner
Prof. Hans Hauner
Technische Universität München
Phone: 089–289 249 –16/ –25
Prof. Andreas Fritsche, Prof. Norbert Stefan,
Tübingen University Hospital
Prof. Julia Szendrödi
German Diabetes Center
Prof. Andreas Pfeiffer
German Institute of Human Nutrition /
Phone: 033200–882778 oder 882774
Prof. Andreas Birkenfeld, Prof. Peter Schwarz, Prof. Stefan Bornstein
Dresden University Hospital
Prof. Peter Nawroth
Heidelberg University Hospital
Phone: 06221 56-8606
Prof. Michael Stumvoll, Dr. Gesine Flehmig
Leipzig University Hospital
Prof. Sebastian Schmid
Schleswig-Holstein University Hospital
Phone: 0451 500 3878
Acute dietary fat intake initiates alterations in energy metabolism and insulin resistanc., J Clin Invest. 2017., 23. Januar 2017. doi:10.1172/JCI89444
Brain Insulin Resistance at the Crossroads of Metabolic and Cognitive Disorders in Humans. Physiol Rev. 2016 Oct;96(4):1169-209. doi: 10.1152/physrev.00032.2015
Interaction between the obesity-risk gene FTO and the dopamine D2 receptor gene ANKK1/TaqIA on insulin sensitivity. Diabetologia. 2016 Dec;59(12):2622-2631, doi: 10.1007/s00125-016-4095-0
TGF-β Contributes to Impaired Exercise Response by Suppression of Mitochondrial Key Regulators in Skeletal Muscle, Diabetes 2016 Oct; 65(10): 2849-2861. doi.org/10.2337/db15-1723
Specific Metabolic Profiles and Their Relationship to Insulin Resistance in Recent-Onset Type 1 and Type 2 Diabetes. J Clin Endocrinol Metab. 2016 May;101(5):2130-40. doi: 10.1210/jc.2015-4133